FORMULATION AND IN-VITRO DRUG RELEASE STUDIES OF OXICONAZOLE NITRATE TRANSDERMAL PATCHES

The present study transdermal patches of the Oxiconazole Nitrate were prepared using polymers like Hydroxypropyl methylcellulose, sodium carboxy methyl cellulose and carbopol 934 with different concentration. The patches (1cm2) were cut and added to a beaker containing 100 mL of phosphate buffered saline10 of pH 7.4. The medium was stirred with magnetic bead. The contents were filtered using whatmann filter paper and the filtrate was examined for the drug content against the reference solution consisting of placebo patches (contains no drug) at 274 nm spectrophotometrically. The patches prepared from HPMC and carbomer (H4 and H5) show more tensile strength than the patches prepared from SCMC and carbomer (H8 and H10). As the concentration of hydrophilic polymer HPMC, SCMC and carbomer were increased there is increase in tensile strength, folding endurance of patches between 74.11 ± 4.231 to 97.56 ± 6.231, drug content uniformity and in vitro release studies.