Author/Authors :
Kobayashi، نويسنده , , Hikaru and Kitano، نويسنده , , Kiyoshi and Saito، نويسنده , , Hiroshi and Aoki، نويسنده , , Kazuo and Narita، نويسنده , , Atsuko and Terada، نويسنده , , Nobuo and Sonoyama، نويسنده , , Masayuki and Uchimaru، نويسنده , , Kaoru and Machii، نويسنده , , Takashi and Motokura، نويسنده , , Toru، نويسنده ,
Abstract :
Prolymphocytic leukemia (PLL) was diagnosed by morphologic and immunophenotypical studies in a 72-year-old Japanese man. Massive splenomegaly was present, but lymphadenopathy was minimal in this case. Chromosomal analysis of peripheral mononuclear cells showed t(11;14)(q13;q32) in all metaphases examined, except for one normal karyotype. Northern blot analysis of RNA prepared from leukemic cells obtained from the patient revealed overexpression of the PRAD1/cyclin D1 proto-oncogene, which has not been described previously in patients with PLL.
