Author/Authors :
Dong، نويسنده , , Dan Feng and Li، نويسنده , , En Xiao and Wang، نويسنده , , Ju Bo and Wu، نويسنده , , Yin Ying and Shi، نويسنده , , Fan and Guo، نويسنده , , Jun Jun and Wu، نويسنده , , Yuan and Liu، نويسنده , , Jun Ping and Liu، نويسنده , , Shan Xi and Yang، نويسنده , , Guang Xiao، نويسنده ,
Abstract :
Anginex is a novel artificial peptide that can inhibit angiogenesis. AdNT4-anginex was constructed by inserting the artificial anginex gene into a recombinant adenoviral vector. We demonstrated that AdNT4-anginex inhibited migration of human endothelial cells, angiogenesis and tumor growth in in vitro and in vivo studies. Tumor growth of human H22 hepatoma in mice was inhibited after AdNT4-anginex treatment for 4 weeks, and a significant decrease in tumor size was observed as compared with the control group. Overall, these studies indicate that AdNT4-anginex is an effective anti-tumor agent, and deserves more attention and research.
Keywords :
Anti-Angiogenesis , Recombinant adenovirus , anginex , Peptide , Angiogenesis
