Title of article
Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis
Author/Authors
I. Martin-Kleiner، نويسنده , , Irena and Gall Troselj، نويسنده , , Koraljka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
12
From page
11
To page
22
Abstract
The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its multifunctionality, it is not easy to understand the extent of its relevance to normal cellular physiology. Accordingly, it is even more difficult understanding its role in carcinogenesis. This review presents critical and focused highlights of data relating to M6P/IGF2R, obtained during more than 25 years of cancer research.
Keywords
M6P/IGF2R , IGF2 , Loss of Heterozygosity , cancer , Mutation
Journal title
Cancer Letters
Serial Year
2010
Journal title
Cancer Letters
Record number
1818262
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