Title of article
A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy
Author/Authors
Zhang، نويسنده , , Qunzhou and Shi، نويسنده , , Shihong and Yen، نويسنده , , Yun and Brown، نويسنده , , Jimmy and Ta، نويسنده , , Joseph Quoc and Le، نويسنده , , Anh D.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
10
From page
151
To page
160
Abstract
The potential role of cancer stem-like cells (CSCs) in chemoresistance of human oral squamous cell carcinoma (OSCC) was examined. A small subpopulation (1–2%) of CD133+ CSCs was identified in OSCC cell lines and tissues. These CD133+ CSCs possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to CD133− counterparts. Meanwhile, CD133+ CSCs were substantially resistant to standard chemotherapy, wherein both in vitro and in vivo treatment with paclitaxel resulted in a marked enrichment for CD133+ CSCs. Our data suggest that CD133+ cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC.
Keywords
Oral squamous cell carcinoma , CD133+ cancer stem-like cell , Chemoresistance
Journal title
Cancer Letters
Serial Year
2010
Journal title
Cancer Letters
Record number
1818319
Link To Document