Title of article :
Malignant trophoblastic neoplasms with different modes of origin
Author/Authors :
Arima، نويسنده , , Takahiro and Imamura، نويسنده , , Toshiro and Sakuragi، نويسنده , , Noriaki and Higashi، نويسنده , , Masahiro and Kamura، نويسنده , , Toshiharu and Fujimoto، نويسنده , , Seiichiro and Nakano، نويسنده , , Hitoo and Wake، نويسنده , , Norio، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
11
From page :
5
To page :
15
Abstract :
The genetic origin of 24 trophoblastic neoplasms was determined using PCR polymorphisms. Based on pregnancy history, these tumors included nine postmolar trophoblastic tumors, 12 tumors preceded by live birth or abortion, and three nongestational tumors. Androgenetic origin was defined in eight post-molar trophoblastic tumors, and the remaining one might have arisen from a normal fertilization. Six tumors retained genetic features carried by the homozygous complete mole. Two tumors showed PCR polymorphism compatible with that of the heterozygous complete mole. tumors in the second class had alleles of both paternal and maternal contribution. However, discordance of sex between the antecedent pregnancy product and the tumor was recognized in three choriocarcinomas. The absence of paternal contribution suggested a parthenogenetic origin of three nongestational choriocarcinomas. The findings that PCR polymorphisms were either homozygous in certain loci or heterozygous in others may mean that the tumor was derived from a germ cell after meiosis I. As a result, at least three subtypes with different modes of origin were demonstrated in the 24 trophoblastic tumors. These findings underscore the importance of precise genetic marker analyses in a large series to clearly identify clinical and biologic characteristics of each subset of tumors.
Journal title :
Cancer Genetics and Cytogenetics
Serial Year :
1995
Journal title :
Cancer Genetics and Cytogenetics
Record number :
1818399
Link To Document :
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