Author/Authors :
Papadhimitriou، نويسنده , , Stefanos I. and Abazis، نويسنده , , Danae and Repa، نويسنده , , Constantina and Papaconstantinou، نويسنده , , Christos and Papanastasiou، نويسنده , , Constantinos and Pangalos، نويسنده , , Constantinos and Stamatelou، نويسنده , , Marina، نويسنده ,
Abstract :
We report a case of chronic myelomonocytic leukemia in which cytogenetic analysis revealed a 47,XY, +1, + der(7)del(7)(q32q36)ins(7;1)(q32;p36.3p22) chromosomal constitution. This abnormal karyotype, which as a whole is new to any myeloid malignancy, points to a possible pathogenetic role for the oncogenes MET and FGR on the derivative chromosome 7, and for the CSF1 and JUN genes flanking the breakpoint on chromosome 1.
