Author/Authors :
Brunel، نويسنده , , Véronique and Sainty، نويسنده , , Danielle and Costello، نويسنده , , Régis and Mozziconacci، نويسنده , , Marie-Joëlle and Simonetti، نويسنده , , Jacqueline and Arnoulet، نويسنده , , Christine and Coignet، نويسنده , , Lionel and Bouabdallah، نويسنده , , Reda and Gastaut، نويسنده , , Jean-Albert and Gabert، نويسنده , , Jean and Lafage-Pochitaloff، نويسنده , , Marina، نويسنده ,
Abstract :
We report the case of a patient having Philadelphia-negative, bcr-abl-positive chronic myeloid leukemia. In situ hybridization showed the presence of the bcr-abl fusion the chromosome 9 long arm in all mitoses observed. Stability of the disease was very difficult to obtain because of serious adverse effects to interferon and chemotherapy, mainly grade IV neutropenia, and a blast crisis occurred 12 months after diagnosis. Only three other patients with such presentation (Philadelphia negative, bcr-abl positive with bcr-abl fusion on the chromosome 9 long arm) have been reported, with a poor therapeutic response and outcome in two of them. Translocation of BCR to chromosome 9 may therefore have a worse prognosis than translocation of ABL to chromosome 22 in Philadelphia-negative chronic myeloid leukemia.
