Title of article :
Translocation(Y;1)(q12;q12) in hematologic malignancies: Report on Two New Cases, FISH Characterization, and Review of the Literature
Author/Authors :
Michaux، نويسنده , , Lucienne and Wlodarska، نويسنده , , Iwona and Velloso، نويسنده , , Elvira Rodrigues Pereira and Verhoef، نويسنده , , Gregor and Van Orshoven، نويسنده , , Angeline and Michaux، نويسنده , , Jean-Louis and Scheiff، نويسنده , , Jean-Marie and Mecucci، نويسنده , , Cristina and Van den Berghe، نويسنده , , Herman، نويسنده ,
Abstract :
Translocation(Y;1)(q12;q21) is a rare cytogenetic anomally occurring in hematologic disorders thought to affect stem cells. We report here on two new cases, one end-stage myelofibrosis and one chronic myelomonocytic leukemia. The translocation breakpoints were assessed by conventional cytogenetic techniques in both cases and by FISH in the second case. A partial trisomy of the 1q21-qter region could be demonstrated. The data of the literature are reviewed and the possible pathogenetic mechanisms are discussed.
