Author/Authors :
Fan، نويسنده , , Shaozhong and Sun، نويسنده , , Zhengbo and Jiang، نويسنده , , Dahe and Dai، نويسنده , , Chao and Ma، نويسنده , , Yibao and Zhao، نويسنده , , Zhenhuan and Liu، نويسنده , , Hui and Wu، نويسنده , , Yingliang and Cao، نويسنده , , Zhijian and Li، نويسنده , , Wenxin، نويسنده ,
Abstract :
Malignant gliomas are the most common primary brain tumors associated with significant morbidity and mortality. How to target the tumor in situ, and inhibit tumor cell proliferation and invasion is the key for therapy. Gliomas express a glioma-specific chloride ion channel that is sensitive to toxins including BmKCT. In the current study, the inhibitory effect of BmKCT on glioma growth was observed in vivo using the glioma/SD rat model. Furthermore, BmKCT prevented the metastasis of glioma cells in vivo. Moreover, biodistribution experiments with l3lI-labeled or Cy5.5-conjugated BmKCT revealed that BmKCT selectively targeted the glioma in situ. Our data suggest that BmKCT could be exploited as a potential therapeutic for glioma diagnosis and therapy.
Keywords :
TARGETING , IN VIVO , scorpion toxin , BmKCT , Gliomas , metastasis , Proliferation
