Author/Authors :
Inaba، نويسنده , , Tohru and Shimazaki، نويسنده , , Chihiro and Yoneyama، نويسنده , , Satoshi and Hirai، نويسنده , , Hideyo and Kikuta، نويسنده , , Takehisa and Sumikuma، نويسنده , , Toshiya and Sudo، نويسنده , , Yoshikazu and Yamagata، نويسنده , , Noboru and Ashihara، نويسنده , , Eishi and Goto، نويسنده , , Hideo and Fujita، نويسنده , , Naohisa and Nakagawa، نويسنده , , Masao، نويسنده ,
Abstract :
A 48-year-old Japanese man was admitted to our hospital because of general fatigue, nasal bleeding, and petechiae on his extremities. He was diagnosed with acute myelomonocytic leukemia with trilineage myelodysplasia (T-MDS). Chromosomal analysis of bone marrow cells revealed t(7;11)(p15;p15), which has been rarely reported but known to be characteristic of Japanese patients. Although t(7;11)(p15;p15) has been reported mainly in acute myelogenous leukemia (AML), it can be occasionally found in so-called stem cell diseases such as chronic myelogenous leukemia or chronic myeloproliferative disorders. Therefore, t(7;11)(p15;p15) might affect trilineage progenitors or stem cells as well as myeloid lineage cells, subsequently resulting in AML with T-MDS, as in our case reported here.
