Title of article :
Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo
Author/Authors :
Tsai، نويسنده , , An-Chi and Pan، نويسنده , , Shiow-Lin and Liao، نويسنده , , Cho-Hwa and Guh، نويسنده , , Jih-Hwa and Wang، نويسنده , , Shih-Wei and Sun، نويسنده , , Hui-Lung and Liu، نويسنده , , Yinan and Chen، نويسنده , , Chien-Chih and Shen، نويسنده , , Chien-Chang and Chang، نويسنده , , Ya-Ling and Teng، نويسنده , , Che-Ming، نويسنده ,
Abstract :
Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization. In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin. Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs. These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy.
Keywords :
Endothelial cells , Angiogenesis , Moscatilin , VEGF , bFGF
