Author/Authors :
Sasano، نويسنده , , N. and Enomoto، نويسنده , , A. and Hosoi، نويسنده , , Y. and Katsumura، نويسنده , , Y. and Matsumoto، نويسنده , , Y. and Morita، نويسنده , , A. and Shiraishi، نويسنده , , K. and Miyagawa، نويسنده , , K. and Igaki، نويسنده , , H. and Nakagawa، نويسنده , , K.، نويسنده ,
Abstract :
Edaravone has been reported to have a radioprotective effect at high concentrations. We now report that a lower dose of edaravone enhanced X-ray-induced apoptosis of some cell lines harboring p53 wild-type status, such as MOLT-4, Nalm-6, and HepG2. The knock-down of p53 using siRNA in MOLT-4 cells abolished the radiosensitizing effect of edaravone. Enhanced phosphorylations of p53 at Ser 15 and Ser 20 and up-regulation of PUMA, a p53 target protein, were observed after X-irradiation in the presence of edaravone. We conclude that the low dose of edaravone sensitized cells to X-irradiation by promoting the p53-dependent apoptotic signaling pathway.
Keywords :
Radiosensitizer , p53 , Edaravone , apoptosis
