Author/Authors :
Pedeutour، نويسنده , , F. and Lacour، نويسنده , , J.P. and Perrin، نويسنده , , C. and Huffermann، نويسنده , , K. and Simon، نويسنده , , M.P. and Ayraud، نويسنده , , N. and Turc-Carel، نويسنده , , C.، نويسنده ,
Abstract :
We have identified a new dermatofibrosarcoma protuberans (DP) case with a t(17;22) (q22;q13) occurring in a child. The translocation was substantiated by the presence of one or two copies of the sole der(22)t(17;22). This rearrangement added to two normal chromosomes 17 and one or two chromosomes 22, resulted in trisomy 22cen-q13 and trisomy (or tetrasomy) 17q22–25. This observation confirms the specificity of the association of DP with the t(17;22) found together with extra copies of the der(22)t(17;22). It also points out a possible prevalence of translocation rather than rings in DP of the childhood disease.
