Author/Authors :
Takahashi، نويسنده , , Naoto and Miura، نويسنده , , Ikuo and Ohshima، نويسنده , , Atsushi and Utsumi، نويسنده , , Seiko and Nimura، نويسنده , , Takashi and Hashimoto، نويسنده , , Keiko and Cyubachi، نويسنده , , Akihiko and Saitoh، نويسنده , , Masahiro and Enomoto، نويسنده , , Katsuhiko and Miki، نويسنده , , Tohru and Hirosawa، نويسنده , , Shinsaku and Miura، نويسنده , , Akira، نويسنده ,
Abstract :
We report a 65-year-old woman with nonHodgkinʹs lymphoma (NHL) carrying a t(3;14)(q27;q11) and BCL6 rearrangement in the affected cells. She had generalized lymphadenopathy and the bone marrow was infiltrated by lymphoma cells at presentation. Histological diagnosis was “malignant lymphoma, diffuse, large cell” type according to an International Working Formulation. Chromosome analysis revealed a t(3;14)(q27;q11), which is a new variant translocation of t(3;14) (q27;q32). Southern blot analysis showed rearrangement of BCL6, JH, and TCRβ but not of TCRδ. Cosmid probe of BCL6 hybridized to 14q11 and 3q27 by fluorescence in situ hybridization (FISH). Although the band 14q11 is a locus of T-cell receptor α- and δ-chains (TCRα/δ), lymphoma cells expressed B-cell, IgGk phenotype. The findings suggest that a novel proto-oncogene in the vicinity of TCRα/δ is involved in this translocation.
