Title of article :
Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells
Author/Authors :
Wang، نويسنده , , Ling and Ling، نويسنده , , Yun and Chen، نويسنده , , Yan and Li، نويسنده , , Cheng-Ling and Feng، نويسنده , , Feng and You، نويسنده , , Qi-Dong and Lu، نويسنده , , Na and Guo، نويسنده , , Qing-Long، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Pages :
7
From page :
42
To page :
48
Abstract :
Baicalein is a widely used Chinese herbal medicine that has been used historically in anti-inflammatory and anti-cancer therapy. However, the molecular mechanism of its anti-cancer activity remains poorly understood and warrants further investigations. The purpose of this study is to verify the activity of baicalein to inhibit the invasion of MDA-MB-231 human breast cancer cells. The results indicated that baicalein suppressed MDA-MB-231 cell adhesion to fibronectin-coated substrate, wound healing migration and invasion through the Matrigel in a concentration-dependent manner. Western blot and gelatin zymography analysis showed that baicalein significantly inhibited the expression and secretion of matrix metalloproteinases 2/9 (MMP-2/9) in MDA-MB-231 cells. Additionally, treatment of MDA-MB-231 cells with baicalein down-regulated the expression of MMP-2/9 involved mitogen-activated protein kinases (MAPK) signaling pathway. Taken together, baicalein had potential to suppress the adhesion, migration and invasion of MDA-MB-231 cancer cells in vitro and it could serve as a promising drug for the treatment of cancer metastasis.
Keywords :
Baicalein , Adhesion , breast cancer , Migration , Invasion , MMP-2 , MMP-9
Journal title :
Cancer Letters
Serial Year :
2010
Journal title :
Cancer Letters
Record number :
1819136
Link To Document :
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