Title of article :
KSHV genotypes A and C are more frequent in Kaposi sarcoma lesions from Brazilian patients with and without HIV infection, respectively
Author/Authors :
Ramos da Silva، نويسنده , , Suzane and Ferraz da Silva، نويسنده , , Ana Paula and Bacchi، نويسنده , , Maura Moscardi and Bacchi، نويسنده , , Carlos Eduardo and Elgui de Oliveira، نويسنده , , Deilson Elgui، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Abstract :
The present study aimed to evaluate the frequency of KSHV genotypes isolated from Kaposi sarcoma (KS) lesions in patients from Brazil. Fifty KS cases were evaluated. The most frequently detected viral genotypes were A (50.0%) and C (48.0%); the B genotype was isolated only in one case (2.0%). Noteworthy, there was a significant predominance of A genotypes in KS lesions from HIV-positive patients, whereas C genotypes were found mostly in the HIV-negative setting. This finding supports the hypothesis that distinct KSHV genotypes have a non-random distribution in KS, which might be attributable to unique biological properties.
Keywords :
HHV-8 , Kaposi sarcoma , KSHV , Viral genotyping
Journal title :
Cancer Letters
Journal title :
Cancer Letters
