Possible role of EBV in breast cancer and other unusually EBV-associated cancers

Epstein–Barr virus (EBV) a ubiquitous gamma herpesvirus persists for life, generally without health consequences. However, it is associated with several well-recognized malignancies, such as Burkitt’s lymphoma and nasopharyngeal carcinoma. A growing list of malignancies has been proposed to be EBV-associated: most of which are consistently EBV-positive whereas others show inconsistent results. The possible contribution of EBV to the development and/or progression of different “non-classical” tumors is discussed in terms of putative “non-traditional’’ infection in EBV-related tumors.