Author/Authors :
Pezzolo، نويسنده , , Annalisa and Coco، نويسنده , , Simona and Raso، نويسنده , , Alessandro and Parodi، نويسنده , , Federica and Pistorio، نويسنده , , Angela and Valdora، نويسنده , , Francesca and Capra، نويسنده , , Valeria and Zollo، نويسنده , , Massimo and Aschero، نويسنده , , Simona and Basso، نويسنده , , Eleonora and Cama، نويسنده , , Armando and Nozza، نويسنده , , Paolo and Gambini، نويسنده , , Claudio and Cinalli، نويسنده , , Giuseppe and Garrè، نويسنده , , Maria Luisa and Iolascon، نويسنده , , Achille and Pistoia، نويسنده , , Vito and Tonini، نويسنده , , Gian Paolo، نويسنده ,
Abstract :
Medulloblastoma (MB) is the most common malignant brain tumor of childhood. We have investigated for novel chromosomal imbalances and prognostic markers of pediatric MB. Forty MBs out of 64, were analyzed using high resolution prometaphase comparative genomic hybridization. Chromosome 10q26.1–q26.3 loss combined with 17q24.3–q25.3 gain and/or 7q34–q36.3 gain in tumors predicted poor patient’s survival. A minimal deleted region of 14.12 cM at 10q26.1–q26.3 was refined by LOH analysis. We propose a new prognostic marker for pediatric MB patient risk stratification based on the presence of 10q26.1–q26.3 loss plus 17q24.3–q25.3 gain and/or 7q34–q36.3 gain associations.
Keywords :
Medulloblastoma , Chromosomal imbalances , CGH , LOH , Fish
