Author/Authors :
Sinke، نويسنده , , Richard J and Dijkhuizen، نويسنده , , Tr?nie and Janssen، نويسنده , , Bert and Weghuis، نويسنده , , Daniël Olde and Merkx، نويسنده , , Gerard and van den Berg، نويسنده , , Eva and Schuuring، نويسنده , , Ed and Meloni، نويسنده , , Aurelia M and de Jong، نويسنده , , Bauke and van Kessel، نويسنده , , Ad Geurts and de Jong، نويسنده ,
Abstract :
Recent cytogenetic analysis of a series of human renal oncocytomas revealed the presence of a recurring chromosomal translocation (5;11)(q35;q13) as sole anomaly in a subset of the tumors. The molecular characterization of this translocation was initiated using two primary t(5;11)-positive renal oncocytomas and a panel of somatic cell hybrids derived from one of these tumors, in conjunction with fluorescence in situ hybridization (FISH) and Southern blot analysis. The breakpoint in chromosome band 11q13 could be located within a genomic interval of at maximum 400 Kb immediately centromeric to the BCL1 locus.
