Author/Authors :
Saitoh، نويسنده , , Kohki and Miura، نويسنده , , Ikuo and Ohshima، نويسنده , , Atsushi and Takahashi، نويسنده , , Naoto and Kume، نويسنده , , Masaaki and Utsumi، نويسنده , , Seiko and Kobayashi، نويسنده , , Yoshimi and Hashimoto، نويسنده , , Keiko and Hatano، نويسنده , , Yoshiaki and Nimura، نويسنده , , Takashi and Saito، نويسنده , , Masahiro and Enomoto، نويسنده , , Katsuhiko and Ohhira، نويسنده , , Miki an، نويسنده ,
Abstract :
The translocation t(8;21)(q22;q22) is found in 40% of cases of acute myeloid leukemia (AML) designated as the subtype M2 in the French-American-British (FAB) classification. The 8;21 translocation is clinically of interest because patients with this subtype have a good prognosis. We describe a masked type of the translocation, t(8;12;21)(q22.1;q24.1;q22.1). The translocation was first interpreted as t(8;12)(q22;q24) based on cytogenetics, but was reevaluated as a result of Southern blot and fluorescence in situ hybridization (FISH) analyses.
