Double minute chromosomes and myelodysplastic syndrome: A case report and literature review

Double minute chromosomes (dmin) occur in about 3.3–10.6% of acute leukemia, especially in the elderly. However, dmins are relatively rare in myelodysplastic syndrome (MDS). We describe a case of refractory anemia with excess blasts associated with complex cytogenetic abnormalities, dmins, and brief survival.