Title of article :
Increased spontaneous formation of micronuclei in cultured fibroblasts of first-degree relatives of familial melanoma patients
Author/Authors :
Berg-Drewniok، نويسنده , , Barbara and Weichenthal، نويسنده , , Michael and Ehlert، نويسنده , , Ulrike and Rümmelein، نويسنده , , Bettina and Breitbart، نويسنده , , Eckhard W. and Rüdiger، نويسنده , , Hugo W.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Pages :
5
From page :
106
To page :
110
Abstract :
The phenomenon of spontaneous increased micronuclei and enhanced UV-sensitivity, which is known for familial cutaneous malignant melanoma (CMM) patients, could be demonstrated again in fibroblasts of 17 familial CMM patients. In order to determine if close relatives of familial CMM patients show both a comparable spontaneous chromosomal instability and enhanced UV-sensitivity, cultured fibroblasts of 24 healthy, first-degree relatives of patients with familial malignant melanoma were investigated. The cytokinesis-block micronucleous technique was used to detect enhanced chromosomal instability. Fibroblasts of the investigated relatives showed a significantly increased spontaneous formation of micronuclei, in comparison to 19 healthy controls, but no enhanced UV-sensitivity was evident. We conclude that chromosomal instability might be a hereditary trait and a causative factor in developing familial malignant melanoma. This supports the concept of a genetic predisposition to familial CMM and may help to identify high-risk family members at a cytogenetic level in addition to the common clinicopathological traits.
Journal title :
Cancer Genetics and Cytogenetics
Serial Year :
1997
Journal title :
Cancer Genetics and Cytogenetics
Record number :
1820313
Link To Document :
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