Title of article :
Two different Philadelphia chromosomes in a cell line from an AML-M0 patient
Author/Authors :
Gonzلlez Garcيa، نويسنده , , Juan Ramَn and Garcés Ruيz، نويسنده , , Oscar Miguel and Delgado Lamas، نويسنده , , JoséLuis and de Lourdes Ramيrez-Dueٌas، نويسنده , , Marيa، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Pages :
4
From page :
111
To page :
114
Abstract :
A second Philadelphia (Ph) chromosome is one of the most common nonrandom secondary chromosome changes in leukemias with 9;22 translocations. It has been suggested, and observed in two studies of masked t(9;22), that the second Ph chromosome is an exact duplication of the entire derivative chromosome 22. In a cytogenetic study of bone marrow cells from an acute myelogenous leukemia patient, a cell line carrying two different Ph chromosomes evidenced by a chromosome 22 centromeric heteromorphism was found. From this observation arose the question whether the second der(22) was a true Ph chromosome or whether it was a deleted chromosome derived from the normal chromosome 22 that did not contain the bcr-abl rearrangement. A fluorescent in situ hybridization (FISH) study with the t(9;22) probe revealed two bcr-abl positive signals on 60 of 100 interphase nuclei. The second Ph could have resulted from a mitotic crossing over; or, analogously to late-appearing Philadelphia chromosomes, it may be derived from a new chromatid translocation between the chromosomes 9 and 22 not involved in the initial t(9;22).
Journal title :
Cancer Genetics and Cytogenetics
Serial Year :
1997
Journal title :
Cancer Genetics and Cytogenetics
Record number :
1820424
Link To Document :
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