Title of article
Nuclear receptor mRNA expression by HBV in human hepatoblastoma cell lines
Author/Authors
Wu، نويسنده , , Shuang and Kanda، نويسنده , , Tatsuo and Imazeki، نويسنده , , Fumio and Nakamoto، نويسنده , , Shingo and Shirasawa، نويسنده , , Hiroshi and Yokosuka، نويسنده , , Osamu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
10
From page
33
To page
42
Abstract
Recent studies have implicated nuclear receptors (NRs) in the development of hepatocarcinogenesis. We assumed that hepatitis B virus (HBV) alters the expression of NRs and coregulators, and compared the gene expression profiling for 84 NRs and related genes between HpeG2.2.15, which secretes complete HBV virion, and HepG2 by real-time RT-PCR with SyBr green. Forty (47.6%) genes were upregulated 2-fold or greater, and only 5 (5.9%) were downregulated 2-fold or more, in HepG2.2.15 compared to HepG2. These results suggest that HBV affects NRs and their related signal transduction, and that they play important roles in viral replication and HBV-related hepatocarcinogenesis.
Keywords
Nuclear receptor , HCC , HDAC , HBV , hepatocarcinogenesis
Journal title
Cancer Letters
Serial Year
2011
Journal title
Cancer Letters
Record number
1820555
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