Title of article :
Nuclear receptor mRNA expression by HBV in human hepatoblastoma cell lines
Author/Authors :
Wu، نويسنده , , Shuang and Kanda، نويسنده , , Tatsuo and Imazeki، نويسنده , , Fumio and Nakamoto، نويسنده , , Shingo and Shirasawa، نويسنده , , Hiroshi and Yokosuka، نويسنده , , Osamu، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Abstract :
Recent studies have implicated nuclear receptors (NRs) in the development of hepatocarcinogenesis. We assumed that hepatitis B virus (HBV) alters the expression of NRs and coregulators, and compared the gene expression profiling for 84 NRs and related genes between HpeG2.2.15, which secretes complete HBV virion, and HepG2 by real-time RT-PCR with SyBr green. Forty (47.6%) genes were upregulated 2-fold or greater, and only 5 (5.9%) were downregulated 2-fold or more, in HepG2.2.15 compared to HepG2. These results suggest that HBV affects NRs and their related signal transduction, and that they play important roles in viral replication and HBV-related hepatocarcinogenesis.
Keywords :
Nuclear receptor , HCC , HDAC , HBV , hepatocarcinogenesis
Journal title :
Cancer Letters
Journal title :
Cancer Letters
