Author/Authors :
Fujita، نويسنده , , Megumi and Yagami، نويسنده , , Tatsurou and Fujio، نويسنده , , Miki and Tohji، نويسنده , , Chiaki and Takase، نويسنده , , Kenkichi and Yamamoto، نويسنده , , Yasuhiro and Sawada، نويسنده , , Kyoko and Yamamori، نويسنده , , Motohiro and Okamura، نويسنده , , Noboru، نويسنده ,
Abstract :
Agonists of peroxisome proliferator-activated receptor gamma (PPARγ) have been examined as chemopreventive and chemotherapeutic agents. The aim was to investigate the cytotoxicity of troglitazone (TGZ) and its mechanisms in terms of PPARγ dependency and the p38 mitogen-activated protein kinase (MAPK) pathway in three human renal cell carcinoma (RCC) cell lines, 786-O, Caki-2 and ACHN cells. TGZ induced apoptosis and exerted cytotoxicity in a PPARγ-independent manner. We demonstrated that TGZ activated the p38 MAPK pathway and was involved in the cytotoxicity of TGZ. It was also revealed that TGZ induced G2/M cell cycle arrest through activation of p38 MAPK.
Keywords :
Troglitazone , apoptosis , renal cell carcinoma , PPAR? , p38 MAPK
