Author/Authors :
Naoi، نويسنده , , Y. and Tanei، نويسنده , , T. and Kishi، نويسنده , , K. and Tsunashima، نويسنده , , R. and Tominaga، نويسنده , , N. and Baba، نويسنده , , Y. and Nakayama، نويسنده , , T. and Shimazu، نويسنده , , K. and Kim، نويسنده , , S.J. and Tamaki، نويسنده , , Y. and NOGUCHI، نويسنده , , S.، نويسنده ,
Abstract :
Association of estrogen receptor (ER), progesterone receptor (PR), HER2, Ki67 and 70-gene classifier (70-GC) with a response to paclitaxel (PAC) (n = 79) or docetaxel (DOC) (n = 55) was investigated in the neoadjuvant setting for breast cancer patients. Sensitivity of breast tumors to PAC, but not to DOC, was found to be significantly associated with ER negativity (P = 0.003), PR negativity (P = 0.007), and Ki67 positivity (P = 0.007). Breast tumors classified into the responders by 70-GC showed a significantly (P = 0.005) higher reduction rate to PAC and interestingly a significantly (P = 0.009) lower reduction rate to DOC than those classified into the non-responders by 70-GC, suggesting that 70-GC might be useful for the differentiation of PAC-sensitive and DOC-sensitive breast tumors.
Keywords :
Paclitaxel , 70-Gene classifier , docetaxel , breast cancer , DNA microarray
