Author/Authors :
Zhu، نويسنده , , Wei and Huang، نويسنده , , Ling and Li، نويسنده , , Yahong and Zhang، نويسنده , , Xu and Gu، نويسنده , , Jianmei and Yan، نويسنده , , Yongmin and Xu، نويسنده , , Xiaomeng and Wang، نويسنده , , Mei and Qian، نويسنده , , Hui and Xu، نويسنده , , Wenrong، نويسنده ,
Abstract :
Mesenchymal stem cells (MSCs) can promote tumor growth in a mouse xenograft model, but the exact mechanism remains unclear. In this study, we investigated the effects of bone marrow MSC-derived exosomes (MSC-exosomes) on tumor growth in vitro and in vivo. Our results showed that MSC-exosomes promoted tumor growth in vivo. MSC-exosomes enhanced vascular endothelial growth factor (VEGF) expression in tumor cells by activating extracellular signal-regulated kinase1/2 (ERK1/2) pathway. Inhibition of ERK1/2 activation reserved the increase of VEGF level by MSC-exosomes. Our findings demonstrate a new mechanism through which MSC-exosome-mediated cell–cell interactions may contribute to tumor progression.
Keywords :
xenograft model , Mesenchymal Stem Cell , Exosome , Tumor growth , MAPK pathway
