Translocation(8;20;21)(q22;q13;q22) in acute myeloblastic leukemia with maturation: A variant form of t(8;21)

A 39-year-old man was diagnosed as having acute myeloblastic leukemia with maturation (AML-M2). Cytogenetic studies revealed 45,X,-Y,t(8;20)(q22;q13)(21]/46,XY[3]. Molecular analysis of the marrow mononuclear cells by reverse transcription -polymerase chain reaction with nested AML1 and ETO primers showed amplification of the AML1/ETO fusion transcript, thus confirming that the chromosomal aberration was in fact a masked t(8;21), i.e., variant t(8;20;21)(q22;q13;q22).