Author/Authors :
Lo، نويسنده , , Paulisally Hau Yi and Ko، نويسنده , , Josephine Mun Yee and Yu، نويسنده , , Zhuo You and Law، نويسنده , , Simon and Wang، نويسنده , , Li Dong and Li، نويسنده , , Ji-Lin and Srivastava، نويسنده , , Gopesh and Tsao، نويسنده , , Sai Wah and Stanbridge، نويسنده , , Eric J. and Lung، نويسنده , , Maria Li، نويسنده ,
Abstract :
The group 2 LIM domain protein, Cysteine-rich intestinal protein 2 (CRIP2) was found to play an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. Subcellular fractionation studies show that CRIP2 is expressed in the nucleus. Real-time quantitative PCR shows CRIP2 expression is down-regulated in ESCC tissues and cell lines. Functional studies reveal that CRIP2 reduces colony formation, growth, and invasion abilities. Furthermore, over-expression of CRIP2 induces apoptosis through induction of active caspases 3 and 9 proteins. In conclusion, this study shows CRIP2 plays an important role in the development of ESCC.
