Author/Authors :
Emilia، نويسنده , , G. and Luppi، نويسنده , , M. and Ferrari، نويسنده , , M.G. and Temperani، نويسنده , , P. and Marasca، نويسنده , , R. and Giacobbi، نويسنده , , F. P. Vaccari، نويسنده , , P. and Bandieri، نويسنده , , E. and Di Donato، نويسنده , , C. and Carapezzi، نويسنده , , C. and Torelli، نويسنده , , G.، نويسنده ,
Abstract :
Ph-positive chronic myeloid leukemia (CML) mimicking essential thrombocythemia (ET) at onset seems to be a distinct clinical entity. Whether this rare clinical form of CML is associated with single, specific variants of BCRIABL transcripts is a matter of debate. Among 82 consecutive patients with Ph-positive CML, we identified 3 patients in which the disease mimicked ET at presentation, because of marked thrombocytosis and moderate leukocytosis, with few immature myeloid cells in peripheral blood and blood basophilia in 2 of them. Molecular analysis with the reverse transcriptase-polymerase chain reaction technique showed the presence of b2a2, b3a2, and b3a2-b2a2 transcript variants in the three patients, respectively. The results of our study together with a review of literature data suggest that different BCRIABL transcript variants may occur in CML mimicking ET, without an apparently significant prevalence of one type.
