Author/Authors :
Chen، نويسنده , , Zhong and Morgan، نويسنده , , Rodman and Notohamiprodjo، نويسنده , , Mathilda and Meloni-Ehrig، نويسنده , , Aurelia and Schuster، نويسنده , , Robert D. and Bennett، نويسنده , , Joseph M. and Cohen، نويسنده , , Jesse B. and Stone، نويسنده , , John F and Sandberg، نويسنده , , Avery A، نويسنده ,
Abstract :
Three cases of acute nonlymphocytic leukemia with a Philadelphia chromosome (Ph) as a secondary abnormality are reported. The Ph was late-appearing in one patient and appeared as an additional anomaly in the other two patients. Fluorescence in situ hybridization studies of the first patient identified the presence of a minor BCR/ABL rearrangement. The findings of these cases support the conclusion that the Ph plays a role not only in leukemogenesis, but also in disease progression. An overview of the literature dealing with similar cases is also presented.
