Author/Authors :
Liu، نويسنده , , Hanshao and Zhu، نويسنده , , Lin and Liu، نويسنده , , Bingya and Yang، نويسنده , , Liu and Meng، نويسنده , , Xianxin and Zhang، نويسنده , , Wei and Ma، نويسنده , , Yueyun and Xiao، نويسنده , , Huasheng، نويسنده ,
Abstract :
Recent studies demonstrated that in several human malignancies aberrant expression profiles of circulating microRNAs (miRNAs) anticipate great cancer diagnostic potential. Here we showed that serum miR-378 could serve as a novel noninvasive biomarker in gastric cancer (GC) detection. Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187*, miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls. Collectively, these data support our contention that serum miR-378 has strong potential as a novel noninvasive biomarker in gastric cancer detection.
Keywords :
Serum microRNA , Genome-wide microRNA expression profile , Gastric cancer , Noninvasive biomarker
