Author/Authors :
Mertens، نويسنده , , Fredrik and Kullendorff، نويسنده , , Carl-Magnus and Hjorth، نويسنده , , Lars and Alumets، نويسنده , , Jan and Mandahl، نويسنده , , Nils، نويسنده ,
Abstract :
Cytogenetic analysis of short-term cultured cells from an immature ovarian teratoma of a 9-year-old girl disclosed an extra copy of chromosome 3 as the sole clonal abnormality. The fact that trisomy 3 was previously reported as the only karyotypic change in two ovarian germ-cell tumors—one teratoma NOS and one immature teratoma—suggests that gain of chromosome 3 constitutes an early and pathogenetically important change in a subset of female germ-cell tumors.
