Author/Authors :
Zhao، نويسنده , , Shuai and Kanno، نويسنده , , Yuichiro and Nakayama، نويسنده , , Momoka and Makimura، نويسنده , , Minami and Ohara، نويسنده , , Shiori and Inouye، نويسنده , , Yoshio، نويسنده ,
Abstract :
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. Recent studies have reported the anti-tumor effects of the AhR in breast cancer. In this study, we investigated the anti-tumor effect of AhR activation based on the cancer stem cell hypothesis. We show that AhR activation suppressed mammosphere formation of MCF-7 cells and decreased the proportion of cells with high ALDH-1 (aldehyde dehydrogenase 1) activity. In addition, we also demonstrate that AhR activation regulates self-renewal signaling by down-regulating Wnt/β-catenin and Notch.
