Author/Authors :
Zhang، نويسنده , , Ju and Lou، نويسنده , , Xiaomin and Yang، نويسنده , , Shangbin and He، نويسنده , , Shun and Yang، نويسنده , , Lei and Liu، نويسنده , , Mei and Zhu، نويسنده , , Hongxia and Shan، نويسنده , , Qiang and Su، نويسنده , , Siyuan and Zhan، نويسنده , , Qimin and Xu، نويسنده , , Ningzhi and Liu، نويسنده , , Siqi، نويسنده ,
Abstract :
Suppression of c-Myc is likely to induce cellular senescence in many tumors with unclear mechanisms. A proteomics survey indicated that high levels of BCL2-associated athanogene 2 (BAG2) were found in response to c-Myc repression in TRE293 cells. This observation led to the investigation into the role of BAG2 in c-Myc-induced senescence. The association of the c-Myc/SP1 complex with the BAG2 promoter verified the role of c-Myc/SP1 in regulating BAG2 transcription. Furthermore, high levels of BAG2 were found to induce p21CIP1-dependent senescence and subsequent carcinogenetic arrest, suggesting its possible role as an indirect activator of the p21CIP1 pathway.
Keywords :
BAG2 , c-Myc , p21CIP1 , senescence , Sp1
