Author/Authors :
Takako and Ichinohasama، نويسنده , , Ryo and Miura، نويسنده , , Ikuo and Shishido، نويسنده , , Tomoaki and Matsumoto، نويسنده , , Keisuke and Shimizu، نويسنده , , Yoshinaka and Miki، نويسنده , , Tohru and DeCoteau، نويسنده , , John F and Kadin، نويسنده , , Marshall E and Ooya، نويسنده , , Kiyoshi، نويسنده ,
Abstract :
A patient with B-cell lineage diffuse large-cell lymphoma carrying the t(3;16)(q27;p11) and BCL-6 rearrangement is described. Cytogenetic studies showed 46,XY,t(3;16)(q27;p11.2)[11]/46,idem,add(18)(q21)[7]/46,XY[2]. The chromosomal translocation involving the 3q27 locus was associated with the BCL-6 gene rearrangement identified by Southern blot analysis. This case involved systemic lymph nodes, as large as 3 cm in diameter, bilaterally in neck, axilla, and inguinal regions. The patient obtained complete remission with chemotherapy.
