Title of article :
A Recurrent Nonrandom Translocation (3;7)(q27;p12) Associated with Bcl-6 Gene Rearrangement in B-Cell Diffuse Large Cell Lymphoma
Author/Authors :
Takako and Ichinohasama، نويسنده , , Ryo and Miura، نويسنده , , Ikuo and Funato، نويسنده , , Tadao and Sato، نويسنده , , Isao and Suzuki، نويسنده , , Chiyuki and Saito، نويسنده , , Yoshiko and Decoteau، نويسنده , , John F. and Myers، نويسنده , , Jerome B. and Kadin، نويسنده , , Marshall E. and Sawai، نويسنده , , Takashi and Ooya، نويسنده , , Kiyoshi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
Two cases of B-cell diffuse large cell lymphoma associated with the t(3;7)(q27;p12) and BCL-6 rearrangement are described. Cytogenetic studies revealed [case 1] 47,XY,t(3;7)(q27;p12),+12 and [case 2] 45,X,−Y,t(3;7)(q27;p12),del(6)(q21q25),+16,−21. The translocation of each case had a non-random chromosomal change involving a 3q27 locus associated with BCL-6 gene rearrangement identified by Southern blot analysis. Both cases involved multiple lymph nodes and extranodal regions, such as stomach and peritoneal cavity in case 1, extranodal retroperitoneal space, subcutis, probable liver, and colon in case 2. Chemotherapy provided only short survival after onset: 17 and 16 months, respectively. Altered expression of adhesion molecules CD44, CD54 (case 1) and CD11a and CD18 (case 2) may help to explain the poor outcome of these patients.
Journal title :
Cancer Genetics and Cytogenetics
Journal title :
Cancer Genetics and Cytogenetics
