Title of article :
The major vault protein mediates resistance to epidermal growth factor receptor inhibition in human hepatoma cells
Author/Authors :
Losert، نويسنده , , Annemarie and Lِtsch، نويسنده , , Daniela and Lackner، نويسنده , , Andreas and Koppensteiner، نويسنده , , Herwig and Peter-Vِrِsmarty، نويسنده , , Barbara and Steiner، نويسنده , , Elisabeth and Holzmann، نويسنده , , Klaus and Grunt، نويسنده , , Thomas L. Schmid، نويسنده , , Katharina and Marian، نويسنده , , Brigitte and Grasl-Kraupp، نويسنده , , Bettina and Schulte-Hermann، نويسنده , , Rolf and Krupitza، نويسنده , , Georg and Berger، نويسنده , , Walter and Grusch، نويسنده , , Michael، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
9
From page :
164
To page :
172
Abstract :
To better understand the response of HCC to EGFR inhibition, we analyzed factors connected to the resistance of HCC cells against gefitinib. Sensitive HCC3 cells co-expressed EGFR and ErbB3 but lacked kinase-domain mutations in EGFR. Interestingly, expression of MVP was restricted to resistant cell lines, whereas ABCB1 and ABCC1 showed no association with gefitinib resistance. Moreover, ectopic MVP expression in HCC3 cells decreased gefitinib sensitivity, increased AKT phosphorylation and reduced the expression of inflammatory pathway-associated genes, whereas silencing of MVP in Hep3B and HepG2 cells increased sensitivity. These findings suggest MVP as a novel player in resistance against EGFR inhibition.
Keywords :
hepatocellular carcinoma , Gefitinib resistance , major vault protein , epidermal growth factor receptor
Journal title :
Cancer Letters
Serial Year :
2012
Journal title :
Cancer Letters
Record number :
1821342
Link To Document :
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