Author/Authors :
Zhang، نويسنده , , Hui and Zhang، نويسنده , , Xiaofang and Wu، نويسنده , , Xiaojuan and Li، نويسنده , , Weiwei and Su، نويسنده , , Rui-Peng and Cheng، نويسنده , , Hongxia and Xiang، نويسنده , , Lei and Gao، نويسنده , , Peng and Zhou، نويسنده , , Gengyin and Liu، نويسنده ,
Abstract :
Multidrug resistance (MDR) represents a major obstacle in the successful treatment of breast cancer. The MDR1 gene is a direct target of the Wnt/β-catenin signaling pathway, which controls tumor development. Overexpression of P-glycoprotein, encoded by the MDR1 gene, is one of the most common causes of MDR. We found that the Frizzled 1 (FZD1) protein, which is an essential component of the Wnt/β-catenin pathway, is overexpressed in the multidrug resistant breast cancer cell subline MCF-7/ADM, coincident with MDR1/P-gp. FZD1 silencing induced down-regulation of MDR1/P-gp, restored sensitivity to four chemotherapy drugs, and significantly decreased cytoplasmic and nuclear β-catenin levels. FZD1 appears to mediate multidrug resistance by regulating the Wnt/β-catenin pathway.
Keywords :
breast cancer , Multidrug resistance , MDR1 , FZD1 , Wnt/?-catenin
