Author/Authors :
Zhong، نويسنده , , Jia-teng and Xu، نويسنده , , Ye-Yuan Yi، نويسنده , , Hao-wei and Su، نويسنده , , Jing and Yu، نويسنده , , Hui-mei and Xiang، نويسنده , , Xi-yan and Li، نويسنده , , Xiao-ning and Zhang، نويسنده , , Zhichao and Sun، نويسنده , , Lian-kun، نويسنده ,
Abstract :
Previous results showed that a novel BH3 mimetic S1 could induce cell death in a wide range of cancer types in vitro through Bax/Bak-dependent apoptosis. We demonstrated that in addition to mitochondrial pathway apoptosis, endoplasmic reticulum (ER) stress-associated apoptosis was also induced by S1. Moreover, S1 can induce autophagy in U251 cells, which may occur through ER stress and disruption of the association of Bcl-2 and Beclin 1. Inhibition of autophagy by the autophagic inhibitors 3-methyladenine (3-MA) or chloroquine (CQ) increased S1-induced apoptosis. In conclusion, autophagy plays an important role in S1-induced U251 cell death.
Keywords :
bcl-2 , ER stress , Autophagy , BH3 mimetic
