Author/Authors :
Yoshida، نويسنده , , Tetsuya and Kimura، نويسنده , , Nobuhiro and Akiyoshi، نويسنده , , Tomi and Ohshima، نويسنده , , Koichi and Nagano، نويسنده , , Mitsuyuki and Morioka، نويسنده , , Eiji and Hisano، نويسنده , , Syusuke and Ohyashiki، نويسنده , , Kazuma and Kamada، نويسنده , , Nanao and Tamura، نويسنده , , Kazuo، نويسنده ,
Abstract :
We report a 71-year-old patient with acute myelomonocytic leukemia (AMMoL) who had complicated chromosomal abnormalities showing diploidy with a jumping translocation of a homogeneously staining region (hsr) and tetraploidy with double minutes (dmin). The analysis of gene amplification showed that hsr and dmin were the results of C-ETS 1 gene amplification. After induction chemotherapy, tetraploidy with dmin completely disappeared, while diploidy with hsr and del(11)(q23) remained until the patient died. It is speculated that hsr is more stable than dmin during chemotherapy and that the presence of tetraploidy is not necessarily a factor of poor response to chemotherapy for acute leukemia.
