Author/Authors :
Chen، نويسنده , , Han and Ko، نويسنده , , Josephine Mun Yee and Wong، نويسنده , , Victor Chun Lam and Hyytiainen، نويسنده , , Marko and Keski-Oja، نويسنده , , Jorma and Chua، نويسنده , , Daniel and Nicholls، نويسنده , , John M. and Cheung، نويسنده , , Florence Man Fung and Lee، نويسنده , , Anne Wing Mui and Kwong، نويسنده , , Dora Lai-wan and Chiu، نويسنده , , Pui Man and Zabarovsky، نويسنده , , Eugene R. and Tsao، نويسنده , , Sai Wah and Tao، نويسنده , , Qian-hua KAN، نويسنده , , Rebecca J. Chan، نويسنده , , Stephen Ho Kin and Stanbridge، نويسنده , , Eric J. and Lung، نويسنده , , Maria Li، نويسنده ,
Abstract :
This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment.
Keywords :
Latent transforming growth factor ? binding protein 2 (LTBP-2) , Nasopharyngeal carcinoma (NPC) , Anti-Angiogenesis , Tumor cell dormancy , Metastatic growth , Tumor suppression
