Title of article
GCF2/LRRFIP1 promotes colorectal cancer metastasis and liver invasion through integrin-dependent RhoA activation
Author/Authors
Ariake، نويسنده , , Kyohei and Ohtsuka، نويسنده , , Hideo and Motoi، نويسنده , , Fuyuhiko and Douchi، نويسنده , , Daisuke and Oikawa، نويسنده , , Masaya and Rikiyama، نويسنده , , Toshiki and Fukase، نويسنده , , Koji and Katayose، نويسنده , , Yu and Egawa، نويسنده , , Shinichi and Unno، نويسنده , , Michiaki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
9
From page
99
To page
107
Abstract
The precise relationship between GCF2 expression and carcinogenesis has not yet been established. To clarify the metastatic potential of GCF2 in colorectal cancer, HT-29 cells stably suppressing GCF2 expression were injected into the spleens of severe combined immunodeficient (SCID) mice. GCF2 suppression reduced the number of metastatic foci in the liver and reduced fibronectin-induced cell adhesion, migration, and invasion. Downstream from the integrin signaling pathways, GCF2 regulates RhoA interaction with the RGS domain of Leukemia associated RhoGEF (LARG). Altogether, our results suggest that GCF2 plays an important role in colorectal cancer metastasis by regulating RhoA-induced cell adhesion, migration, and invasion.
Keywords
RhoA , Colorectal Cancer , Integrin , GCF2 , LRRFIP1
Journal title
Cancer Letters
Serial Year
2012
Journal title
Cancer Letters
Record number
1821899
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