Author/Authors :
Ren، نويسنده , , Hui and Chen، نويسنده , , Mingwei and Yue، نويسنده , , Ya-ping and Tao، نويسنده , , Hui and Owonikoko، نويسنده , , Taofeek K. and Ramalingam، نويسنده , , Suresh S. and Khuri، نويسنده , , Fadlo R. and Sun، نويسنده , , Shi-Yong، نويسنده ,
Abstract :
This study focuses on determining whether the combination of NYP-BKM120 (BKM120) and RAD001 exerts enhanced therapeutic effect against lung cancer. The combination of BKM120 and RAD001 exerted synergistic inhibitory effects on the growth of lung cancer cells both in culture and in mouse xenograft model. This combination abrogated RAD001-induced Akt phosphorylation and exerted enhanced suppressive effect on 4EBP1 phosphorylation. Collectively, we suggest that the combination of RAD001 and BKM120 may be an effective regimen for treatment of lung cancer, hence warranting further evaluation of the combination in the clinic.
Keywords :
BKM120 , PI3 Kinase , lung cancer , mTOR , RAD001
