Author/Authors :
de Graaff، نويسنده , , Willem E and van Echten، نويسنده , , Jannie and van der Veen، نويسنده , , Anneke Y and Sleijfer، نويسنده , , Dirk Th and Timmer، نويسنده , , Albertus and Koops، نويسنده , , Heimen Schraffordt and de Jong، نويسنده , , Bauke، نويسنده ,
Abstract :
The first published chromosomal pattern of the retroperitoneal lymph node metastasis of a malignant gonadal stroma cell tumor of the adult testis is presented. Karyotyping showed structural chromosomal abnormalities and loss of the Y-chromosome. This loss was confirmed in primary tumor and metastasis using fluorescence in situ hybridization (FISH). The characteristic chromosomal abnormality of adult testicular germ cell tumors, an i(12p), was not present. The results are compared with other data of testicular and ovarian sex cord stromal tumors. From the comparison of the male tumors, it is concluded that loss of the Y-chromosome might have a pathogenetic significance.
