Title of article
Characterization of the C-MYC Amplicon in a Case of Acute Myeloid Leukemia with Double Minute Chromosomes
Author/Authors
Crossen، نويسنده , , Peter G. and Savage، نويسنده , , Lynette M and Heaton، نويسنده , , David C and Morrison، نويسنده , , Mary J، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
5
From page
144
To page
148
Abstract
We have characterized the double minute chromosomes in a case of acute myeloid leukemia (AML). Southern blot analysis showed that the C-MYC was amplified. Further analysis with probes located both 3′ and 5′ of MYC indicated that the amplicon was at least 700 kb in size, extending from the papilloma virus integration site situated 500 kb 5′ of MYC to the PVT gene located 280 kb 3′ of MYC. This appears to be the largest MYC-containing amplicon in human leukemia.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
1999
Journal title
Cancer Genetics and Cytogenetics
Record number
1822111
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