Author/Authors :
Shan، نويسنده , , Qiang and Lou، نويسنده , , Xiaomin and Xiao، نويسنده , , Ting and Zhang، نويسنده , , Ju and Sun، نويسنده , , Huiying and Gao، نويسنده , , Yanning and Cheng، نويسنده , , Shujun and Wu، نويسنده , , Lin and Xu، نويسنده , , Ningzhi and Liu، نويسنده , , Siqi، نويسنده ,
Abstract :
Cancer/testis antigens (CTAs) are highly immunogenic in many tumors, especially in non-small cell lung cancer (NSCLC). A low-density protein microarray, which consisted of 72 CTAs and six non-CTAs, was used to screen for lung cancer-related autoantibodies. The CTA panel of NY-ESO-1, XAGE-1, ADAM29 and MAGEC1, had sensitivity and specificity values of 33% and 96%, respectively. When examined in a test set, this panel of markers had sensitivity and specificity values of 36% and 89%, respectively. This array of markers preferentially detected NSCLC, but did not detect breast cancer, and non-cancer lung disease.
Keywords :
Cancer/testis antigen (CTA) , non-small cell lung cancer (NSCLC) , Protein microarray , Biomarker
