Title of article
A Novel Chromosomal Rearrangement Associated with Therapy-Related Acute Leukemia
Author/Authors
Powell، نويسنده , , James and Traweek، نويسنده , , Thomas and Beatty، نويسنده , , Orren and Qumsiyeh، نويسنده , , Mazin B and Rosoff، نويسنده , , Philip M، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
5
From page
173
To page
177
Abstract
We describe a 7-year-old girl with therapy-related acute myeloid leukemia (AML) associated with a single and novel karyotypic abnormality. The patient had been treated with alkylating agents and etoposide for hypothalamic pilocytic astrocytoma at age 17 months, and developed mixed lineage AML. Cytogenetic analysis of the leukemic blasts showed 46,XX,der(7)t(7;11)(q22;q14) in all cells examined. Southern blot analysis revealed three copies of an unrearranged MLL gene on chromosome 11q. This is the first report of a triplicated, unrearranged MLL gene in association with a deletion of 7q anomaly and an unbalanced translocation in therapy-related leukemia.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
1999
Journal title
Cancer Genetics and Cytogenetics
Record number
1822133
Link To Document