Author/Authors :
Wu، نويسنده , , Jia and Ji، نويسنده , , Xiaowei and Zhu، نويسنده , , Linlin and Jiang، نويسنده , , Qiaoli and Wen، نويسنده , , Zhenzhen and Xu، نويسنده , , Song-Xue Shao، نويسنده , , Wei and Cai، نويسنده , , Jianting and Du، نويسنده , , Qin and Zhu، نويسنده , , Yongliang and Mao، نويسنده , , Jianshan، نويسنده ,
Abstract :
Abnormal cytokinesis increases the possibility of nuclear fusion in tumor cells. However, the role of microRNAs (miRNAs) in abnormal cytokinesis is unclear. Here, we found that miR-1290 was significantly up-regulated in clinical colon cancer tissues. Up-regulation of miR-1290 postponed cytokinesis and led to the formation of multinucleated cells. KIF13B was a target of miR-1290 that was involved in aberrant cytokinesis. Furthermore, enforced expression of miR-1290 activated the Wnt pathway and increased the reprogramming-related transcript factors c-Myc and Nanog. Our results suggest that up-regulation of miR-1290 in colon cancer cells impaired cytokinesis and affected reprogramming.
Keywords :
KIF13B , Colon cancer , miR-1290 , Cytokinesis
